- 专利标题： Reversible covalent linkage of functional molecules
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申请号： US15045906申请日： 2016-02-17
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公开(公告)号： US10174094B2公开(公告)日： 2019-01-08
- 发明人: Mark Smith , Stephen Caddick , James Baker , Vijay Chudasama
- 申请人： UCL Business Plc
- 申请人地址： GB London
- 专利权人： UCL Business Plc
- 当前专利权人： UCL Business Plc
- 当前专利权人地址： GB London
- 代理机构： Dorf & Nelson LLP
- 代理商 Scott D. Locke, Esq.
- 优先权： GB0913965.0 20090810; GB0913967.6 20090810; GB0914321.5 20090814
- 主分类号： C07K14/655
- IPC分类号： C07K14/655 ; C07K14/435 ; G01N33/58 ; C07D207/456 ; C07D207/416 ; C07D209/52 ; A61K49/00 ; A61K47/60 ; A61K47/55 ; A61K47/62
摘要：
The present invention relates to the use of a compound containing a moiety of formula (I) as a reagent for linking a compound of formula R1—H which comprises a first functional moiety of formula F1 to a second functional moiety of formula F2 wherein X, X′, Y, R1, F1 and F2 are as defined herein. The present invention also provides related processes and products. The present invention is useful for creating functional conjugate compounds, and specifically conjugates in which at least one of the constituent molecules carries a thiol group.
公开/授权文献
- US20160176942A1 Reversible Covalent Linkage of Functional Molecules 公开/授权日：2016-06-23
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