An implantable occlusion and tissue ingrowth resistant fluid interface is provided with a housing, an orifice and a catheter port. The housing is formed from at least one biocompatible material and is configured without sharp edges or corners. The housing at least partially defines an internal housing cavity. The orifice member at least partially defines an orifice between the internal housing cavity and an exterior of the housing. The orifice has an elongated transverse cross-section configured with a length that is at least four times its maximum width. The catheter port is located on the housing and is configured to couple with a catheter such that the internal housing cavity is in fluid communication with a lumen of the catheter when the catheter is coupled to the catheter port. Embodiments having a moving cylinder, a rotor, and non-chemical surface modifications, as well as methods of use are also disclosed.