发明授权
- 专利标题: Pyrazole compound
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申请号: US15990026申请日: 2018-05-25
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公开(公告)号: US10183913B2公开(公告)日: 2019-01-22
- 发明人: Izumi Sasaki , Tomohiro Toyoda , Hidefumi Yoshinaga , Itaru Natsutani , Yoko Takahashi
- 申请人: Sumitomo Dainippon Pharma Co., Ltd.
- 申请人地址: JP Osaka
- 专利权人: SUMITOMO DAINIPPON PHARMA CO., LTD.
- 当前专利权人: SUMITOMO DAINIPPON PHARMA CO., LTD.
- 当前专利权人地址: JP Osaka
- 代理机构: Wenderoth, Lind & Ponack, L.L.P.
- 优先权: JP2010-160705 20100715
- 主分类号: C07D231/20
- IPC分类号: C07D231/20 ; C07D231/18 ; C07D231/38 ; C07D405/06 ; C07D493/08
摘要:
The present invention relates to a novel serotonin reuptake inhibitor which also exhibits 5-HT2C antagonistic action (antidepressive and anxiolytic effects), in particular, 5-HT2C inverse agonistic action comprising Compound (1): or a pharmaceutically acceptable salt thereof wherein R1, R2, R3 and R4 are independently hydrogen or C1-6 alkyl etc.; R5 is C4-7 alkyl or —(CR8R9)r-E; R6, R7, R8 and R9 are independently hydrogen, fluorine or C1-6 alkyl; A is C6-10 aryl or heteroaryl etc.; r is 1, 2, 3 or 4; E is C3-8 cycloalkyl or C6-10 aryl etc.; L is oxygen, sulfur or —NR10—; n is 1, 2 or 3; R10 is hydrogen or C1-6 alkyl etc.; and X is hydrogen or halogen etc.
公开/授权文献
- US20180273489A1 PYRAZOLE COMPOUND 公开/授权日:2018-09-27
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