- 专利标题: Pyrrolobenzodiazepines and conjugates thereof
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申请号: US15510397申请日: 2014-09-10
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公开(公告)号: US10188746B2公开(公告)日: 2019-01-29
- 发明人: Philip Wilson Howard
- 申请人: MEDIMMUNE LIMITED
- 申请人地址: GB Cambridge, Cambridgeshire
- 专利权人: MEDIMMUNE LIMITED
- 当前专利权人: MEDIMMUNE LIMITED
- 当前专利权人地址: GB Cambridge, Cambridgeshire
- 代理机构: Casimir Jones, S.C.
- 代理商 Melissa E. Kolom
- 国际申请: PCT/EP2014/069248 WO 20140910
- 国际公布: WO2016/037644 WO 20160317
- 主分类号: A61K31/5517
- IPC分类号: A61K31/5517 ; C07D519/00 ; C07D487/04 ; A61K47/68
摘要:
A conjugate of formula (A): Wherein Y is selected from formulae A1 and A2: Z1 is a C1-3 alkylene group; Z2 is a C1-3 alkylene group; Q is: where QX is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue; L is a linker connected to a cell binding agent; CBA is the cell binding agent; and n is an integer between 0 and 48.
公开/授权文献
- US20170340752A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF 公开/授权日:2017-11-30
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