Invention Grant
- Patent Title: Neprilysin inhibitors
-
Application No.: US15841749Application Date: 2017-12-14
-
Publication No.: US10189823B2Publication Date: 2019-01-29
- Inventor: Melissa Fleury , Adam D. Hughes
- Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
- Applicant Address: US CA South San Francisco
- Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Wendy Petka
- Main IPC: C07D405/12
- IPC: C07D405/12 ; C07D231/20 ; A61K31/4192 ; A61K31/421 ; A61K31/42 ; A61K45/06 ; A61K31/415 ; C07D231/14 ; C07D249/04 ; C07D261/18 ; C07D263/38

Abstract:
In one aspect, the invention relates to compounds having the formula: where X, Ra, Rb, R2, and R7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Public/Granted literature
- US20180237423A1 NEPRILYSIN INHIBITORS Public/Granted day:2018-08-23
Information query