- 专利标题： Method for treating fibrosis using siRNA and a retinoid-lipid drug carrier
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申请号： US15283179申请日： 2016-09-30
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公开(公告)号： US10195145B2公开(公告)日： 2019-02-05
- 发明人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
- 申请人： Nitto Denko Corporation
- 申请人地址： JP Osaka
- 专利权人： Nitto Denko Corporation
- 当前专利权人： Nitto Denko Corporation
- 当前专利权人地址： JP Osaka
- 代理机构： Baker & Hostetler LLP
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K9/127 ; C12N15/11 ; A61K31/713 ; C07H21/02
摘要：
What is described is a method for treating a fibrotic disease by administering a pharmaceutical composition comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.
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