Example methods, apparatus, systems, and computer-readable storage media are provided to sense and protect against liquid in contact with a mobile electronic device. An example method includes determining, with one or more of a plurality of liquid sensors, that liquid has come into contact with at least one of an internal surface of a mobile electronic device and an external surface of a mobile electronic device. In response to the determining that liquid has come into contact with the at least one of an internal surface of a mobile electronic device and an external surface of a mobile electronic device, the method includes informing a user of the mobile electronic device that the mobile electronic device has come into contact with the liquid, and sealing a port of the mobile electronic device.