A distributed system may implement logical control groups for distributed system resources. A request for a particular system resource may be received at a request routing tier for a distributed system that is implemented by multiple computing systems in different respective availability zones. One or more resource control nodes of a resource control tier for the distributed system that are members of a logical control group for the particular system resource may be discovered. A logical control group for the particular system resource may include at least one resource control node in a different availability zone than the availability zone that includes the particular system resource. The request may then be sent to one of the discovered resource control nodes in the logical control group in order to service the request for the particular system resource.