The present disclosure relates to an array substrate, a display panel, a display device and a driving method. The array substrate includes a plurality of sub-pixel dot matrix units. In each of the plurality of sub-pixel dot matrix units, the sub-pixels in a same row are connected to data lines arranged on a same side of the sub-pixels respectively, the sub-pixels in the rows where the sub-pixels are arranged in a same sequence are connected to the data lines in a same direction, and two first base color sub-pixels in at least two adjacent rows are connected to a same data line.