Systems and methods for orbital angular momentum (OAM)-based multidimensional signaling with multiple-input-multiple-output (MIMO). The wireless communication is achieved using a transmitter including a plurality of orthogonal pulse shapers of a multidimensional modulator, the plurality of orthogonal pulse shapers generating a multidimensional modulated signal by imposing one or more data sequences on corresponding mutually orthogonal filter impulse responses derived from multiple orthogonal basis functions including Slepian sequences. An OAM antenna array including OAM antenna elements is used such that each of the OAM antenna elements includes an azimuthal phase shifter for shifting an azimuthal phase term of a wavefront generated by an antenna element such that the OAM antenna elements impose the multidimensional modulated signal on pre-determined OAM modes of a carrier signal corresponding to the azimuthal phase term.