Invention Grant
- Patent Title: 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases
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Application No.: US15333148Application Date: 2016-10-24
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Publication No.: US10208024B2Publication Date: 2019-02-19
- Inventor: Steven W. Andrews , James F. Blake , Adam Cook , Indrani W. Gunawardana , Kevin W. Hunt , Andrew T. Metcalf , David Moreno , Li Ren , Tony P. Tang
- Applicant: Array BioPharma, Inc.
- Applicant Address: US CO Boulder
- Assignee: Array BioPharma Inc.
- Current Assignee: Array BioPharma Inc.
- Current Assignee Address: US CO Boulder
- Agency: Fish & Richardson P.C.
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D401/14 ; C07D413/14 ; A61K31/501 ; A61K31/5377 ; C12Q1/68 ; A61K45/06 ; C12Q1/6886 ; G01N33/574
Abstract:
Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.
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