Invention Grant
- Patent Title: Inhibitors of HIF prolyl hydroxylase
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Application No.: US15513854Application Date: 2015-09-23
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Publication No.: US10208060B2Publication Date: 2019-02-19
- Inventor: Jiaqiang Cai , Alejandro Crespo , John Debenham , Xiaoxing Du , Ping Liu , Rongqiang Liu , Christina B. Madsen-Duggan , Weiguo Quan , Christopher Sinz , Liping Wang
- Applicant: Jiaqiang Cai , Alejandro Crespo , John Debenham , Xiaoxing Du , Ping Liu , Rongqiang Liu , Christina B. Madsen-Duggan , Weiguo Quan , Christopher Sinz , Liping Wang
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Matthew A. Leff; Laura M. Ginkel
- Priority: CNPCT/CN2014/087696 20140928
- International Application: PCT/US2015/051570 WO 20150923
- International Announcement: WO2016/049098 WO 20160331
- Main IPC: C07D491/048
- IPC: C07D491/048 ; C07D495/04 ; A61P7/06
Abstract:
The present invention concerns compounds of formula I or a pharmaceutically acceptable salt thereof which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
Public/Granted literature
- US20170313718A1 INHIBITORS OF HIF PROLYL HYDROXYLASE Public/Granted day:2017-11-02
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