A stain removal device adapted to at least partially surround a stain located on a fabric to activate in a targeted manner includes a shell comprising a wall with an inner surface, an outer surface, a rim defining an aperture in the shell, the rim being defined by the inner and outer surfaces and the inner surface defining a shell cavity, at least one opening extending through the wall of the shell between the inner and outer surfaces of the shell, a dispensable cleaning agent at least partially disposed within the shell cavity, and an attachment portion at least partly coupled to the shell. The attachment portion is configured to removably couple the stain removal device to a fabric or article of clothing such that the rim of the shell contacts the fabric and at least partially surrounds a stain located on the fabric. So configured, the dispensable cleaning agent may activate in a targeted manner relative to the stain during a wash cycle.