A disc pick-and-place device for picking and clamping multiple discs and unloading the multiple discs is provided. The disc pick-and-place device includes a supporting body, multiple picking members and a driver. The picking members are disposed around a support body and flexibly abut the edges of the discs. Each picking member includes a flexible rod, a first carrying portion and a second carrying portion. The first carrying portion and the second carrying portion are located on the flexible rod and separated by an interval. The first carrying portion and the second carrying portion partly overlap with each other in an axial direction of the flexible rod. The driver is for driving each flexible rod to rotate and move each first carrying portion and each second carrying portion to a disc releasing position or a disc holding position.