A method for regulating the charge pressure pboost of a supercharged internal combustion engine is disclosed. The method may include adjusting each of two wastegates, a variable turbine geometry, and a downstream compressor bypass valve to regulate engine boost pressure as a function of a first setpoint value for pressure between compressors and a pressure difference in a first regulation loop, a second setpoint value for pressure downstream of multiple compressors, and the pressure difference in a second regulation loop.