An air spring actuated slider pin release system for a semi-trailer slider includes an actuator shaft oriented to extend in generally parallel relationship to at least one of a pair of parallel main members, being connected to the slider for axial rotation, and having a transverse lever arm secured to each end of the shaft for common rotation. Each lever arm has an end connected to a retractable, biased lock pin via a link so that rotation of the shaft and the lever arms causes retraction of the associated lock pin relative to the main member. The actuator shaft has a normally projecting air spring bracket. An air spring is disposed between one of the main members and the air spring bracket so that inflation of the air spring acts on the air spring bracket, axially rotating the shaft and the lever arms for retracting the lock pins.