- 专利标题： Method of modulating the activity of adrenomedullin in a subject in need of therapeutic intervention for organ dysfunction or organ failure associated with adranomedullin (ADM) activity by administering an anti-adrenomedullin (ADM) antibody or an anti-ADM antibody fragment to the subject
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申请号： US15044474申请日： 2016-02-16
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公开(公告)号： US10221238B2公开(公告)日： 2019-03-05
- 发明人: Andreas Bergmann
- 申请人： ADRENOMED AG
- 申请人地址： DE Hennigsdorf
- 专利权人： ADRENOMED AG
- 当前专利权人： ADRENOMED AG
- 当前专利权人地址： DE Hennigsdorf
- 代理机构： Millen White Zelano and Branigan, PC
- 代理商 John Sopp
- 优先权： EP11189447 20111116; EP12160014 20120316
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/26 ; G01N33/68 ; A61K31/137 ; A61K38/22 ; A61K39/00 ; A61K45/06
摘要：
Subject matter of the present invention is an anti-adrenomedullin (ADM) antibody or an anti-adrenomedullin antibody fragment or an anti-ADM non-Ig scaffold for use in therapy of a chronical or acute disease or acute condition of a patient for prevention or reduction of organ dysfunction or organ failure. In a preferred embodiment subject matter of the invention is an anti-ADM antibody or an anti-adrenomedullin antibody fragment or anti-ADM non-Ig scaffold for use in therapy of a chronical or acute disease or acute condition of a patient for prevention or reduction of kidney dysfunction or kidney failure or liver dysfunction or liver failure.
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