- 专利标题： Evaluation probe for central nervous system permeability, evaluation method for central nervous system permeability, and screening method using an evaluation probe for central nervous system permeability
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申请号： US13397759申请日： 2012-02-16
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公开(公告)号： US10227337B2公开(公告)日： 2019-03-12
- 发明人: Toshio Tanaka , Kohei Watanabe , Tsuyoshi Nomoto , Mie Okano , Taichi Shintou , Takeshi Miyazaki , Yuhei Nishimura , Yasuhito Shimada
- 申请人： Toshio Tanaka , Kohei Watanabe , Tsuyoshi Nomoto , Mie Okano , Taichi Shintou , Takeshi Miyazaki , Yuhei Nishimura , Yasuhito Shimada
- 申请人地址： JP Tokyo
- 专利权人： CANON KABUSHIKI KAISHA
- 当前专利权人： CANON KABUSHIKI KAISHA
- 当前专利权人地址： JP Tokyo
- 代理机构： Venable LLP
- 优先权： JP2011-030778 20110216; JP2011-187500 20110830
- 主分类号： C07D417/06
- IPC分类号： C07D417/06 ; C07D417/14 ; C09B23/04 ; C09B23/06 ; G01N33/50
摘要：
Provided is an evaluation probe capable of optically evaluating permeability of a substance through a central nervous system tissue. Also provided is an evaluation method for permeability of a substance through a central nervous system tissue using an evaluation probe for central nervous system permeability. Also provided is a screening method using an evaluation probe for central nervous system permeability. The evaluation probe for central nervous system permeability includes, as an active ingredient, at least one kind of compound represented by the following general formula (1).
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