The present invention provides a hollow-fiber membrane blood purification device obtained by filling a container with a hollow-fiber membrane, in which the hollow-fiber membrane contains a hydrophobic polymer, a hydrophilic polymer and a lipid-soluble substance; the amount of the lipid-soluble substance on the inner surface of the hollow-fiber membrane is 10 mg/m2 or more and 300 mg/m2 or less; and the oxygen transmission rate of the container is 1.8×10−10 cm3·cm/(cm2·s·cmHg) or less.