Invention Grant
- Patent Title: Substituted nitrogen-containing heterocyclic derivatives, pharmaceutical compositions comprising the same and applications of antitumor thereof
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Application No.: US15128298Application Date: 2015-03-21
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Publication No.: US10233180B2Publication Date: 2019-03-19
- Inventor: Xiaowu Dong , Jia Li , Bo Yang , Yongzhou Hu , Yubo Zhou , Qinjie Weng , Wenhu Zhan , Lei Xu , Tao Liu , Qiaojun He
- Applicant: ZHEJIANG UNIVERSITY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Zhejiang CN Shanghai
- Assignee: ZHEJIANG UNIVERSITY,SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: ZHEJIANG UNIVERSITY,SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Zhejiang CN Shanghai
- Agency: Scully, Scott, Murphy & Presser, P.C.
- Priority: CN201410108818 20140322; CN201410124591 20140330; CN201510101220 20150308
- International Application: PCT/CN2015/704813 WO 20150321
- International Announcement: WO2015/144021 WO 20151001
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D413/14 ; C07D417/14
Abstract:
Disclosed are new substituted nitrogen-containing heterocyclic derivatives represented by formula (I) as AKT inhibitors, optical isomers, pharmaceutically acceptable salts or solvates thereof, wherein the definition of R1, R2, R3, R4, R5, R6, ring A, ring C, B, Q, Y, Z and m is shown in the description for details. In addition, medicaments comprising the derivatives as active components are also disclosed, which can be useful for treating proliferative diseases, such as cancer and inflammation, especially diseases relating to AKT kinase.
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