Invention Grant
- Patent Title: Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
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Application No.: US15677959Application Date: 2017-08-15
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Publication No.: US10233192B2Publication Date: 2019-03-19
- Inventor: Kyriacos C. Nicolaou , Min Lu , Debashis Mandal , Sanjeev Gangwar , Naidu S. Chowdari , Yam B. Poudel
- Applicant: WILLIAM MARSH RICE UNIVERSITY , BRISTOL-MYERS SQUIBB COMPANY , THE SCRIPPS RESEARCH INSTITUTE
- Applicant Address: US TX Houston US CA La Jolla US NJ Princeton
- Assignee: WILLIAM MARSH RICE UNIVERSITY,THE SCRIPPS RESEARCH INSTITUTE,BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: WILLIAM MARSH RICE UNIVERSITY,THE SCRIPPS RESEARCH INSTITUTE,BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US TX Houston US CA La Jolla US NJ Princeton
- Agency: Parker Highlander PLLC
- Main IPC: C07D491/08
- IPC: C07D491/08 ; A61K47/68
Abstract:
In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
Public/Granted literature
- US20180065976A1 DERIVATIVES OF UNCIALAMYCIN, METHODS OF SYNTHESIS AND THEIR USE AS ANTITUMOR AGENTS Public/Granted day:2018-03-08
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