- 专利标题： Lipopolysaccharide-targeted peptide mimic vaccine against Q fever
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申请号： US15195586申请日： 2016-06-28
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公开(公告)号： US10233233B2公开(公告)日： 2019-03-19
- 发明人: Guoquan Zhang
- 申请人： Guoquan Zhang
- 申请人地址： US MO Columbia
- 专利权人： The Curators of the University of Missouri
- 当前专利权人： The Curators of the University of Missouri
- 当前专利权人地址： US MO Columbia
- 代理机构： Shook, Hardy & Bacon L.L.P.
- 主分类号： C07K7/08
- IPC分类号： C07K7/08 ; A61K39/00 ; C07K16/12
摘要：
A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID NO: 7) (m1E41920) or SPPWHKHELHRK (SEQ ID NO: 8) (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.
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