A method and system is provided for estimation of sensor data confidence based on statistical analysis of different classifier and feature-set (CF) configurations. A method may include: training a classifier of a CF configuration based on a training set of nominal sensor data values; executing the classifier on the training set to generate a first set of confidence values; collecting statistics on the confidence values; calculating a confidence decision threshold based on the collected statistics; executing the classifier on an evaluation set of nominal and degraded sensor data values, to generate a second set of confidence values; deciding whether the sensor data values of the evaluation set are nominal or degraded based on a comparison of the second set of confidence values to the confidence decision threshold; and calculating a score to evaluate the trained classifier based on a verification of the decisions.