A pixel array, comprising multiple pixel units; each pixel unit comprises three sub-pixels in different colors, the three sub-pixels being a red sub-pixel (R), a green sub-pixel (G) and a blue sub-pixel (B) respectively; the connecting lines between central points of the three sub-pixels form a triangle, and each sub-pixel is a cruciform consisting of a rectangle with an aspect ratio of 3:1 in the transverse direction and the longitudinal direction respectively, and having equal lengths in the transverse direction and the longitudinal direction. Also provided are a method of driving the pixel array and a display panel comprising the pixel array. Driving the pixel array with the driving method enables the display panel to have higher visual resolution.