Invention Grant
- Patent Title: 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
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Application No.: US15533804Application Date: 2015-12-11
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Publication No.: US10239843B2Publication Date: 2019-03-26
- Inventor: Alison E. McGonagle , Allan Jordan , Bohdan Waszkowycz , Colin Hutton , Ian Waddell , James R. Hitchin , Kate Mary Smith , Niall M. Hamilton
- Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
- Applicant Address: GB London
- Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
- Current Assignee: CANCER RESEARCH TECHNOLOGY LIMITED
- Current Assignee Address: GB London
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Priority: GB1422098.2 20141212
- International Application: PCT/GB2015/053883 WO 20151211
- International Announcement: WO2016/092326 WO 20160616
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D239/96 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D215/227 ; C07D217/22 ; C07D217/24 ; C07D401/06 ; C07D403/06 ; C07D403/14 ; C07D405/06 ; C07D409/14 ; C07D239/88 ; C07D239/90 ; C07D239/91 ; C07D413/06 ; C07D417/06 ; C07D241/44 ; C07D417/14 ; C07D237/32 ; C07D471/04
Abstract:
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
Public/Granted literature
- US20180016242A1 2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG Public/Granted day:2018-01-18
Information query
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