- 专利标题： 2,4-dioxo-quinazoline-6-sulfonamide derivatives as inhibitors of PARG
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申请号： US15533804申请日： 2015-12-11
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公开(公告)号： US10239843B2公开(公告)日： 2019-03-26
- 发明人: Alison E. McGonagle , Allan Jordan , Bohdan Waszkowycz , Colin Hutton , Ian Waddell , James R. Hitchin , Kate Mary Smith , Niall M. Hamilton
- 申请人： CANCER RESEARCH TECHNOLOGY LIMITED
- 申请人地址： GB London
- 专利权人： CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人： CANCER RESEARCH TECHNOLOGY LIMITED
- 当前专利权人地址： GB London
- 代理机构： Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- 优先权： GB1422098.2 20141212
- 国际申请： PCT/GB2015/053883 WO 20151211
- 国际公布： WO2016/092326 WO 20160616
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; C07D239/96 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D215/227 ; C07D217/22 ; C07D217/24 ; C07D401/06 ; C07D403/06 ; C07D403/14 ; C07D405/06 ; C07D409/14 ; C07D239/88 ; C07D239/90 ; C07D239/91 ; C07D413/06 ; C07D417/06 ; C07D241/44 ; C07D417/14 ; C07D237/32 ; C07D471/04
摘要：
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.
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