A wearable computer is configured to use beamforming techniques to isolate a user's speech from extraneous audio signals occurring within a physical environment. A microphone array of the wearable computer may generate audio signal data from an utterance from a user's mouth. A motion sensor(s) of the wearable computer may generate motion data from movement of the wearable computer. This motion data may be used to determine a direction vector pointing from the wearable computer to the user's mouth, and a beampattern may be defined that has a beampattern direction in substantial alignment with the determined direction vector to focus the microphone array on the user's mouth for speech isolation.