Invention Grant
- Patent Title: Substituted imidazo[1,2-a]pyrazines as soluble guanylate cyclase activators
-
Application No.: US15575978Application Date: 2016-05-23
-
Publication No.: US10245264B2Publication Date: 2019-04-02
- Inventor: Joie Garfunkle , Olga Ornoski , Dann L. Parker, Jr. , Subharekha Raghavan , Libo Xu
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Eric A. Meade; John C. Todaro
- International Application: PCT/US2016/033692 WO 20160523
- International Announcement: WO2016/191334 WO 20161201
- Main IPC: A61K31/4985
- IPC: A61K31/4985 ; C07D487/04 ; A61K31/519 ; A61K45/06 ; C07D519/00 ; A61P9/08
![Substituted imidazo[1,2-a]pyrazines as soluble guanylate cyclase activators](/abs-image/US/2019/04/02/US10245264B2/abs.jpg.150x150.jpg)
Abstract:
A compound of Formula I or a pharmaceutically acceptable salt thereof, are capable of modulating the body's production of cyclic guanosine monophosphate (“cGMP”) and are generally suitable for the therapy and prophylaxis of diseases which are associated with a disturbed cGMP balance. The invention furthermore relates to processes for preparing compounds of Formula I, or pharmaceutically acceptable salt thereofs, for their use in the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of Formula I or pharmaceutically acceptable salts thereof.
Public/Granted literature
- US20180147208A1 IMIDAZO-PYRAZINYL DERIVATIVES USEFUL AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS Public/Granted day:2018-05-31
Information query
IPC分类: