- 专利标题： TMPRSS6 iRNA compositions and methods of use thereof
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申请号： US15603560申请日： 2017-05-24
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公开(公告)号： US10246713B2公开(公告)日： 2019-04-02
- 发明人: James Butler , Martin Maier , Kevin Fitzgerald , Shannon Fishman , Donald Foster , Vasant Jadhav , Stuart Milstein
- 申请人： Alnylam Pharmaceuticals, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： McCarter & English, LLP
- 代理商 Maria Laccotripe Zacharakis; Deborah L. Nagle
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07H21/02 ; C12N15/113 ; A61K31/713 ; A61K45/06
摘要：
The invention relates to RNAi agents, e.g., double-stranded RNAi agents, targeting the TMPRSS6 gene, and methods of using such RNAi agents to inhibit expression of TMPRSS6 and methods of treating subjects having a TMPRSS6 associated disorder, e.g., an iron overload associated disorder, such as β-thalassemia or hemochromatosis.
公开/授权文献
- US20170362594A1 TMPRSS6 iRNA COMPOSITIONS AND METHODS OF USE THEREOF 公开/授权日：2017-12-21
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