Invention Grant
- Patent Title: Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating GPR30/GPER activity
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Application No.: US15556055Application Date: 2016-03-02
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Publication No.: US10251870B2Publication Date: 2019-04-09
- Inventor: Eric R. Prossnitz , Matthias Barton , Matthias R. Meyer
- Applicant: STC.UNM
- Applicant Address: US NM Albuquerque
- Assignee: STC.UNM
- Current Assignee: STC.UNM
- Current Assignee Address: US NM Albuquerque
- Agent Henry D. Coleman; R. Neil Sudol
- International Application: PCT/US2016/020452 WO 20160302
- International Announcement: WO2016/144647 WO 20160915
- Main IPC: A61K31/436
- IPC: A61K31/436 ; A61K31/435 ; A61K31/4355 ; A61K31/437 ; A61K31/16 ; A61K31/7088 ; A61K38/28

Abstract:
The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
Public/Granted literature
Information query
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