System and methods for using secure isolated technology to prevent piracy and cheating on electronic devices. In some examples, an electronic device can use hardware based secure isolated technology to store a first portion of an application in computer memory, and store a second portion of the application in a hardware based secure isolated region of the computer memory, the second portion of the application including an encrypted portion and a plaintext portion The electronic device can further use the hardware based secure isolated technology to establish a secure encrypted communication channel with a server, send data to the server via the secure encrypted communication channel, receive a decryption key from the server via the secure encrypted communication channel, and decrypt encrypted portion using the decryption key. The electronic device can then execute the application using the first portion of the application and the second portion of the application.