A cloud checking and killing method for combating an anti-antivirus test includes receiving, by a cloud sever, a cloud checking and killing request for performing virus checking and killing on a sample. The method further includes analyzing the cloud checking and killing request, and determining whether the cloud checking and killing request is a cloud checking and killing request of an anti-antivirus test. If the cloud checking and killing request is a cloud checking and killing request of an anti-antivirus test, returning, by the cloud server, to the client a cloud checking and killing result that the sample does not carry a virus. If the cloud checking and killing request is not a cloud checking and killing request of an anti-antivirus test, comparing the sample with a virus library of the cloud server to determine whether the sample carries a virus and performing corresponding virus checking and killing.