A handheld cleaner is provided. The handheld cleaner includes: a dust cup assembly comprising: a cup casing; a device housing configured to have a tube shape and disposed in the cup casing, wherein an outer end face of the device housing at an axial side thereof abuts against or extends out of a partial inner surface of the cup casing, and a dust removal chamber is defined between an inner surface of the cup casing and an outer peripheral surface of the device housing and surrounds the device housing along a circumferential direction of the device housing; and a negative pressure device located within the device housing and configured to enable dusty air to enter the dust removal chamber for dust and air separation; a holding assembly mounted to the dust cup assembly and configured for handholding.