Systems and methods are provided for separating oxygen from air using a sorption/desorption cycle that includes a reduced or minimized difference between the maximum and minimum pressures involved in the sorption/desorption cycle. The reduced or minimized difference in pressures can be achieved in part by using valves that can allow for commercial scale flow rates while avoiding large pressure drops for flows passing through the valves. A rotary wheel adsorbent is an example of a system that can allow for a sorption/desorption cycle with reduced and/or minimized pressure drops across valves associated with the process. Stationary adsorbent beds can also be used in combination with commercially available valves that have reduced and/or minimized pressure drops.