Invention Grant
- Patent Title: Hyperphenylalaninemia and treatments thereof
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Application No.: US15752454Application Date: 2016-08-11
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Publication No.: US10265303B2Publication Date: 2019-04-23
- Inventor: Aurora Martinez , Oscar Aubi Catevilla , Lars Skjærven , Jarl Underhaug , Ming Ying , Knut Teigen
- Applicant: BERGEN TEKNOLOGIOVERFØRING AS
- Applicant Address: NO Bergen
- Assignee: BERGEN TEKNOLOGIOVERFØRING AS
- Current Assignee: BERGEN TEKNOLOGIOVERFØRING AS
- Current Assignee Address: NO Bergen
- Agency: Fox Rothschild LLP
- Priority: GB1514489.2 20150814
- International Application: PCT/EP2016/069184 WO 20160811
- International Announcement: WO2017/029202 WO 20170223
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61P3/00 ; A61K31/506 ; A61K31/522 ; A61K45/06
Abstract:
The present invention relates to compounds of formula (I) as defined in the specification for use as pharmacological chaperones having a stabilizing effect on phenylalanine hydroxylase (PAH) for the treatment of hyperphenylalaninemia (HPA), in particular phenylketonuria (PKU). The compounds include trimethoprim and analogues and derivatives thereof.
Public/Granted literature
- US20190008839A1 HYPERPHENYLALANINEMIA AND TREATMENTS THEREOF Public/Granted day:2019-01-10
Information query
