A system and method for perfusion imaging includes an imaging device (122) configured to collect perfusion information from a target area. A processing module (110) is configured to determine perfusion levels of the target area based on the perfusion information. A planning module (114) is configured to provide a treatment plan for the target area by correlating the perfusion levels with treatment activities for the target area, wherein the treatment activities are adjusted based upon characteristics of the perfusion levels in the target area.