- 专利标题： Organocatalytic asymmetric synthesis of antidepressants
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申请号： US15320483申请日： 2015-06-22
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公开(公告)号： US10266481B2公开(公告)日： 2019-04-23
- 发明人: Venkataramasubramanian Vaithiyanathan , Rupali Gundappa Kalshetti , Sudalai Arumugam
- 申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
- 申请人地址： IN New Delhi
- 专利权人： Council of Scientific & Industrial Research
- 当前专利权人： Council of Scientific & Industrial Research
- 当前专利权人地址： IN New Delhi
- 代理机构： Baker & Hostetler LLP
- 优先权： IN1658/DEL/2014 20140620
- 国际申请： PCT/IN2015/050048 WO 20150622
- 国际公布： WO2015/193921 WO 20151223
- 主分类号： C07C209/68
- IPC分类号： C07C209/68 ; C07C211/28 ; C07C211/29 ; C07C211/38 ; C07C269/06 ; C07C271/12 ; C07C271/14 ; C07C271/18
摘要：
The present invention relates to a short enantioselective synthesis of 1-amino aryl tetraline compounds of Formula 1 via nucleophilic enamine catalysis using organocatalyst such as proline. wherein R1 and R2 represent independent of each other hydrogen, (un)substituted or substituted amine; R3 and R4 represent independent of each other hydrogen or halogen.
公开/授权文献
- US20170158607A1 ORGANOCATALYTIC ASYMMETRIC SYNTHESIS OF ANTIDEPRESSANTS 公开/授权日：2017-06-08
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