An example method for zero touch configuration and synchronization of a service appliance in a network environment includes receiving, at an appliance port on a service appliance, an indication that a switch port on a switch changed from an inactive status to an active status, the appliance port being connected over a network to the switch port, starting a bootstrap protocol, including by receiving at the service appliance from the switch, a bootstrap message from a service executing in the switch, creating, by the service appliance, an empty port channel at the service appliance, adding, by the service appliance, the appliance port to the port channel, and associating, by the service appliance, the service to the port channel in a cache.