Invention Grant
- Patent Title: Cytotoxic peptides and conjugates thereof
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Application No.: US15822930Application Date: 2017-11-27
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Publication No.: US10280139B2Publication Date: 2019-05-07
- Inventor: Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Shifeng Pan , Tetsuo Uno , Yongqin Wan , Xing Wang
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- Main IPC: C07D207/09
- IPC: C07D207/09 ; C07K5/02 ; A61K47/68 ; C07D401/12 ; C07D403/12 ; C07D403/14 ; C07D413/12 ; C07K16/32

Abstract:
Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
Public/Granted literature
- US20180155281A1 CYTOTOXIC PEPTIDES AND CONJUGATES THEREOF Public/Granted day:2018-06-07
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