Invention Grant
- Patent Title: Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
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Application No.: US15680424Application Date: 2017-08-18
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Publication No.: US10287291B2Publication Date: 2019-05-14
- Inventor: Fukang Yang , Qian Zhang , Lawrence B. Snyder , Sanjeev Gangwar , Dale L. Boger
- Applicant: BRISTOL-MYERS SQUIBB COMPANY , THE SCRIPPS RESEARCH INSTITUTE
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Yuan Chao
- Main IPC: C07D487/04
- IPC: C07D487/04 ; C07D519/00 ; A61K31/407 ; A61K31/437 ; A61K47/68 ; A61P35/00 ; A61K39/00
Abstract:
seco-Cyclopropapyrroloindole compounds of formula (I) where Hal, R1, R2, and R3 are as defined in the application, are potent anti-cancer agents that can be used in antibody-drug conjugates.
Public/Granted literature
- US20180051031A1 SECO-CYCLOPROPAPYRROLOINDOLE COMPOUNDS, ANTIBODY-DRUG CONJUGATES THEREOF, AND METHODS OF MAKING AND USE Public/Granted day:2018-02-22
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