Various aspects of a surgical assistive device and method to provide assistance in neurosurgery are disclosed herein. The surgical assistive device includes circuitry that determines initial positional shift in the anatomical portion of a subject caused by an incision into a protective portion. A first depth value is estimated based on the plurality of stereo images that are captured from different specified positions of the surgical image capture device to capture views of the anatomical surface of the anatomical portion through the incision. A residual shift in a position of a surgical region of interest is determined with respect to the estimated first depth value. Surgical guidance information is generated to indicate a correct depth of the surgical region of interest in a surgical cavity, based on the determined residual shift. Display of the generated surgical guidance information is controlled on a display screen coupled to the surgical assistive device.