- 专利标题: Pharmaceutical compositions and methods of blocking Bacillus anthracis
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申请号: US14695445申请日: 2015-04-24
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公开(公告)号: US10293040B1公开(公告)日: 2019-05-21
- 发明人: Albert B. Deisseroth
- 申请人: MicroVAX, LLC
- 申请人地址: US VA Warrenton
- 专利权人: MICROVAX, LLC
- 当前专利权人: MICROVAX, LLC
- 当前专利权人地址: US VA Warrenton
- 代理商 Jacob Frank; Glenn Snyder
- 主分类号: A61K39/07
- IPC分类号: A61K39/07 ; C07K14/32 ; C07K14/435 ; A61K39/00
摘要:
The present invention is directed to pharmaceutical compositions and methods of inhibiting or blocking one or more virulence antigenic factors of Bacillus anthracis. Specifically, it involves the administering of an expression vector alone or in conjunction with a fusion protein. The expression vector has a transcription unit encoding a fusion protein composed of an antigenic factor of Bacillus anthracis attached through a linker to the aminoterminal end of the CD40 ligand. This fusion protein has the ability to generate antibodies which prevents Bacillus anthracis infection in an individual.
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