Invention Grant
- Patent Title: Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
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Application No.: US15568051Application Date: 2015-09-18
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Publication No.: US10294206B2Publication Date: 2019-05-21
- Inventor: Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
- Applicant: FORMA TM2, Inc.
- Applicant Address: US MA Watertown
- Assignee: FORMA TM2, INC.
- Current Assignee: FORMA TM2, INC.
- Current Assignee Address: US MA Watertown
- Agency: Choate, Hall & Stewart LLP
- Agent John P. Rearick; Christopher K. Haley
- International Application: PCT/US2015/051056 WO 20150918
- International Announcement: WO2016/171755 WO 20161027
- Main IPC: C07D215/227
- IPC: C07D215/227 ; C07D401/12 ; C07D401/14 ; C07D403/12 ; C07D405/12 ; C07D413/12 ; C07D417/12 ; C07D471/04 ; C07D487/04 ; C07D498/04 ; C07D519/00 ; A61P35/00
Abstract:
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula (I) where A, B, U, V, Z, W1, W2, W3, and R1-R6 are described herein.
Public/Granted literature
- US20180141910A1 FUSED-BICYCLIC ARYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS Public/Granted day:2018-05-24
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