Methods and systems for synchronization of configuration files of a plurality of blades in a virtual application distribution chassis are disclosed. In an exemplary method, a master blade processes a configuration command, updates a first configuration file with the configuration command and generates an updated tag, and sends a configuration message to at least one slave blade of the virtual application distribution chassis informing of the updated configuration file. The configuration message is received by a given slave blade of the one or more slave blades and compared with a second configuration file stored at the given slave blade; and in response to determining that the updated tag in the configuration message is more recent than the tag in the second configuration file stored at the given slave blade, the slave blade sends a request for the updated configuration file to the master blade.