Multiple application modules (MAMs) for monitoring of signals in components in wireless distribution systems (WDSs), including but not limited to distributed antenna systems (DASs) are disclosed. The MAMs are wireless telecommunication circuitry associated with wireless distribution components in a WDS, such as communications and power components as examples. By associating MAMs into components of a WDS, live signals in the WDS can be monitored and measured for monitoring the performance of components within the WDS. The MAMs include a multiple application software platform architecture that includes one or more application layer applications configured to receive and monitor signals in the WDS, and to provide application level information about such monitored signals to other systems or technicians. The application level information can be used by a technician or other system to diagnose or calibrate the WDS and/or the communications components provided therein.