A system and method for distributed graphics processing unit (GPU) computation are disclosed. A particular embodiment includes: receiving a user task service request from a user node; querying resource availability from a plurality of slave nodes having a plurality of graphics processing units (GPUs) thereon; assigning the user task service request to a plurality of available GPUs based on the resource availability and resource requirements of the user task service request, the assigning including starting a service on a GPU using a distributed processing container and creating a corresponding uniform resource locator (URL); and retaining a list of URLs corresponding to the resources assigned to the user task service request.