Synchronous, differential signaling may be performed over a communications path through a wired connection between a master device and a slave device to provide high-bandwidth and/or low-latency communications. Flexibility may be provided in the signaling protocol by providing for a configurable frame structure. Flexibility may be provided in mapping of data streams to bit slots in a frame, varying a number of downlink and uplink slots, configuring a number of turnarounds and locations of the turnarounds within a frame, configuring location and number of control word bit (CWB) slots in a frame, and/or adjusting a clock frequency of the communications link.