Invention Grant
- Patent Title: Therapeutic compounds and uses thereof
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Application No.: US15686028Application Date: 2017-08-24
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Publication No.: US10308614B2Publication Date: 2019-06-04
- Inventor: Brian K. Albrecht , Alexandre Cote , Terry Crawford , Martin Duplessis , Andrew Charles Good , Yves LeBlanc , Steven R. Magnuson , Christopher G. Nasveschuk , F. Anthony Romero , Yong Tang , Alexander M. Taylor
- Applicant: GENENTECH, INC. , CONSTELLATION PHARMACEUTICALS, INC.
- Applicant Address: US CA South San Francisco US MA Cambridge
- Assignee: GENENTECH, INC.,CONSTELLATION PHARMACEUTICALS, INC.
- Current Assignee: GENENTECH, INC.,CONSTELLATION PHARMACEUTICALS, INC.
- Current Assignee Address: US CA South San Francisco US MA Cambridge
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: C07D237/20
- IPC: C07D237/20 ; C07D401/04 ; C07D403/04 ; C07D403/12 ; C07D403/14 ; C07D405/04 ; C07D405/14 ; C07D413/04 ; C07D413/14 ; C07D471/04 ; C07D471/10 ; C07D487/08 ; C07D498/10 ; A61K31/50 ; A61K31/51 ; C07D401/12 ; C07D237/22 ; C07D417/14 ; C07D413/12 ; C07D451/02 ; C07D487/04 ; A61K45/06 ; A61K31/337 ; A61K31/437 ; A61K31/501
Abstract:
The present invention relates to compounds of formula (I): and salts thereof, wherein: R1-R4 have any of the values defined in the specification, and compositions and uses thereof. The compounds are useful as inhibitors of BRG1, BRM and/or PB1. Also included are pharmaceutical compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various BRG1-mediated disorders, BRM-mediated disorders and/or PB1-mediated disorders.
Public/Granted literature
- US20180086720A1 THERAPEUTIC COMPOUNDS AND USES THEREOF Public/Granted day:2018-03-29
Information query
