- 专利标题： Methods and compositions for treating autoimmune disorders by targeting Kv1.3 ion channels with functionalized lipid-derived nanovesicles
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申请号： US15683180申请日： 2017-08-22
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公开(公告)号： US10308942B2公开(公告)日： 2019-06-04
- 发明人: Laura Conforti , Yeoheung Yun
- 申请人： University of Cincinnati , North Carolina Agricultural and Technical State University
- 申请人地址： US OH Cincinnati US NC Greensboro
- 专利权人： University of Cincinnati,North Carolina Agricultural and Technical State University
- 当前专利权人： University of Cincinnati,North Carolina Agricultural and Technical State University
- 当前专利权人地址： US OH Cincinnati US NC Greensboro
- 代理机构： Dinsmore & Shohl LLP
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/02 ; C07H21/04 ; C12N15/113 ; A61K31/713 ; A61K9/00 ; A61K9/127 ; A61K47/69 ; C07K16/28
摘要：
Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout siRNA, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of T cells by selectively targeting memory T cells with the nanoparticles, which deliver their siRNA cargo into the cytosol of the TM cell thus reducing ion channel expression and decreasing Ca2+ influx.
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