- 专利标题： Compositions and methods for selectively inhibiting intestinal carboxylesterase 2 enzyme activity
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申请号： US15754133申请日： 2016-08-18
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公开(公告)号： US10314811B2公开(公告)日： 2019-06-11
- 发明人: Ren Kong , Hong Zhao , Stephen T. C. Wong
- 申请人： The Methodist Hospital
- 申请人地址： US TX Houston
- 专利权人： The Methodist Hospital
- 当前专利权人： The Methodist Hospital
- 当前专利权人地址： US TX Houston
- 代理机构： Cesari and McKenna, LLP
- 国际申请： PCT/US2016/047544 WO 20160818
- 国际公布： WO2017/034919 WO 20170302
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61P1/12 ; A61K31/12 ; A61K45/06 ; A61K31/121 ; A61K31/352 ; A61K31/353 ; A61K31/4745
摘要：
A method for treating diarrhea induced by a chemotherapy agent by administering a carboxylesterase 2 (CES2) inhibitor, i.e., hesperetin, naringenin, or 2′,4′-dihydroxychalcone. Also disclosed is a method for treating cancer by administering a chemotherapy agent together with hesperetin, naringenin, or 2′,4′-dihydroxychalcone. Furthermore, a composition for treating cancer is provided, the composition containing a chemotherapy agent and hesperetin, naringenin, or 2′,4′-dihydroxychalcone.
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