The present disclosure relates to systems and methods for automatically re-routing unmanned aerial vehicles (UAVs). In one implementation, a system for automatically re-routing a UAV includes at least one processor configured to: retrieve a plurality of requests to deposit currency using the UAV, generate a first route including at least two of the requests such that an associated expected total amount of currency is less than a depository threshold; transmit the first route to the UAV; receive, from the UAV, an indication that an amount of currency collected at a location is greater than an amount of currency included in the request associated with the location; revise the expected total amount accordingly; when the revised expected total amount exceeds the depository threshold, generate a second route having an associated expected total amount below the depository threshold; and transmit the second route to the UAV to override the first route.